Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 214-277-2 | CAS number: 1119-40-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted method of estimation for risk assessment
Data source
Reference
- Reference Type:
- other: Estimate
- Title:
- Estimation of Dermal Absorption Rate for Dimethyl glutarate using U.S. EPA DERMWIN v2.01 (September 2010)
- Author:
- INVISTA
- Year:
- 2 011
- Bibliographic source:
- unpublished
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated using U.S. EPA DERMWIN v2.01 (September 2010)
- Principles of method if other than guideline:
- The Dermal Permeability Coefficient Program (DERMWIN) estimates the dermal permeability coefficient (Kp) and the dermally absorbed dose per event (DAevent) of organic compounds.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl glutarate
- EC Number:
- 214-277-2
- EC Name:
- Dimethyl glutarate
- Cas Number:
- 1119-40-0
- Molecular formula:
- C7H12O4
- IUPAC Name:
- 1,5-dimethyl pentanedioate
- Details on test material:
- CAS No.: 001119-40-0
SMILES : O=C(OC)CCCC(=O)OC
CHEM : Pentanedioic acid, dimethyl ester
MOL FOR: C7 H12 O4
MOL WT : 160.17
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: Estimate
- Strain:
- other: Estimate
Administration / exposure
- Details on study design:
- Log Kow (user-entered): 0.49 (used in Kp calculations)
GENERAL Equation: log Kp = -2.72 + 0.71 log Kow - 0.0061 MW
Results and discussion
Any other information on results incl. tables
GENERAL Equation: Kp (predicted): 4.19e-004 cm/hr
Dermally Absorbed Dose per Event:
Water Conc (mg/cm3): 26 (estimated by program)
Event Duration (hr): 1
DA(event): 2.77e-002 mg/cm2-event
(tau = 0.843 hr, t* = 2.02 hr)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
