Reaction mass of ammonium sulphate and potassium sulfate and sodium sulphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

no data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data agiven.

Data source

Reference

Reference Type:

publication

Title:

Toxicology of Ammonium Sulfate in the Lung.

Author:

Pepelko WE et al.

Year:

1980

Bibliographic source:

Bull Environ Contam Toxicol 24: 156-160.

Materials and methods

Principles of method if other than guideline:

Guinea pigs were exposed for a single 8 h period. Twenty animals were exposed to a concentration of 800 -900 mg/m³, six to a concentration of 600 -700 mg/m³ and six to a concentration of 500 - 600 mg/m³. The animals were observed for mortality and signs of gross toxicity.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ammonium sulphate

EC Number:

231-984-1

EC Name:

Ammonium sulphate

Cas Number:

7783-20-2

Molecular formula:

H8N2O4S

IUPAC Name:

diammonium sulfate

Details on test material:

- Name of test material (as cited in study report): ammonium sulfate
No further data

Test animals

Species:

guinea pig

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation: aerosol

Vehicle:

other: water

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Ammonium sulphate aerosol was generated from an aqueous solution with either one or two Retec nebulizers (Retec Development Laboratory, Portland, Oregon) and dried by mixing with dry air and passing it through a heated glass tube. Two nebulizers were used at concentrations greater than 500 mg/m³. Ammonium sulphate concentration was determined by collecting the aerosol on a Gelman A- E glass fiber filter at a flow rate of 2 L/min for 15 min and weighing the filter. Accuracy of the method was periodically checked by chemical analysis of the filter sample. Particle size was evaluated gravimetrically using an Andersen multi-stage sampler (Andersen Sampler Inc., Atlanta, Georgia).
No further data.

Analytical verification of test atmosphere concentrations:

yes

Remarks:

gravimetrically using an Andersen multi-stage sampler (Andersen Sampler Inc., Atlanta, Georgia)

Duration of exposure:

8 h

Concentrations:

500-600, 600-700, 800-900 mg/m³

No. of animals per sex per dose:

6 -20

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 800 mg/m³ air

Based on:

test mat.

Exp. duration:

8 h

Mortality:

Mortality rates:
500-600 mg/m³: 0/6
600-700 mg/m³: 1/6
800-900 mg/m³: 8/20
The animals dying during exposure appeared to do so as a result of acute shock and airway constriction. Any sudden noise or other disturbance was likely to precipitate such an event. After exposure, the survivors recovered without any noticable effect.

Any other information on results incl. tables

0/6, 1/6, and 8/20 animals exposed to an aerosol of the test substance at concentrations of 500 -600, 600 -700, and 800 -900 mg/m³, respectively, died.

Applicant's summary and conclusion

Executive summary:

Six, 6, and 20 guinea pigs were exposed for 8 hours to an aerosol of the test substance at concentrations of 500 -600, 600 -700, and 800 -900 mg/m³, respectively. The animals were observed for mortality and signs of gross toxicity. 0/6, 1/6, and 8/20 animals exposed to the low, mid, and high concentration, respectively, died. The animals dying during exposure appeared to do so as a result of acute shock and airway constriction. Any sudden noise or other disturbance was likely to precipitate such an event. After exposure, the survivors recovered without any noticable effect.