D-pentose, oligomeric, C16 and C18 alkyl glycosides

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No deviation from OECD-402 guideline, but is not GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

GLP compliance:

no

Remarks:

But procedure follows GLP requirements.

Test type:

standard acute method

Limit test:

yes

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

solid: flakes

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

water

Duration of exposure:

48h

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

yes, concurrent vehicle

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

>= 2 000 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Dermal acute tox in rat can be considered as higher than 2000 mg/kg bw for APPyclean-6669 (called previously "Xyliance").

Executive summary:

No mortality and absolutely no clinical signs occured during the study with APPyclean-6669 (APP C16-18). Dermal acute tox can be considered as higher than 2000 mg/kg bw by dermal route in rat. No classification is needed. Please see full details about the absence of rat acute toxicity in APP category report.