Registration Dossier
Registration Dossier
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EC number: 617-251-2 | CAS number: 816431-72-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar - Jul 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 2002
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-{[(2-methoxyphenyl)formamido]sulfonyl}benzoyl chloride
- EC Number:
- 617-251-2
- Cas Number:
- 816431-72-8
- Molecular formula:
- C15H12ClNO5S
- IUPAC Name:
- 4-{[(2-methoxyphenyl)formamido]sulfonyl}benzoyl chloride
- Test material form:
- solid: bulk
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to classification criteria the test substance is not an irritant to the skin. There were no systemic intolerance reactions.
- Executive summary:
The irritant/ corrosive potentail of the test item (Amidchlorid, CAS 816431-72-8) was studie on the skin of rabbits. The method used complied with OECD TG 404 (version 2002). The test item is not an irritant to the skin and does not require classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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