Registration Dossier
Registration Dossier
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EC number: 406-850-2 | CAS number: 133855-98-8 BAS 480 F
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The test substance does not significantly accumulate in organisms
Key value for chemical safety assessment
- BCF (aquatic species):
- 70 L/kg ww
Additional information
Experimental data are available for the assessment of bioaccumulation potential of epoxiconazole. A GLP study conducted according to the EPA OPP 165-4 (Laboratory Studies of Pesticide Accumulation in Fish) was performed with O. mykiss as a test organism. This flow-through study was performed with two test concentrations: 0.001 and 0.005 mg/L. Apparent steady state was reached after 3 days in whole fish and in edible tissue, and after 14 days in viscera. After termination of the exposure, radioactivity levels in fish tissues decreased rapidly with a half-life of 0.7 to 0.9 days. Bioconcentration factors were low: 70 and 59 l/kg for both dose levels (in whole fish, Baranowski, 1990). No marked differences between the two exposure levels were observed.
In addition, a GLP study conducted according to OECD 305 is also available. A Rainbow Trout was used a test specie in this study. The supplementary fish bioaccumulation study with Epoxiconazole showed that accumulation and elimination of radioactivity followed a first order kinetics in inedible tissue and whole fish whilst bi-phasic kinetics was observed in edible tissue. The rapid elimination of Epoxiconazole by rainbow trout resulted in relatively low bioconcentration factors of 63/65 for the whole fish of the fluorophenyl and chlorophenyl label experiment, respectively (exposure level of 5µg/L, BASF AG, rep. no.: 2002/1000001, 2002).
Overall, based on the available experimental data for epoxiconazole it can be concluded that the test substance does not significantly accumulate in organisms.
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