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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EUR 20268
Version / remarks:
European Commission Technical Guidance Document EUR 20268, Determination of particle size distribution, fibre length and diameter distribution of chemical substances (2002)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
cascade impaction
Type of particle tested:
primary particle
Type of distribution:
mass based distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
4-acetyl-2-methylbenzoic acid
EC Number:
856-079-4
Cas Number:
55860-35-0
Molecular formula:
C10H10O3
IUPAC Name:
4-acetyl-2-methylbenzoic acid
Test material form:
solid: particulate/powder

Results and discussion

Mass median aerodynamic diameter:
4.08 µm
Geometric standard deviation:
2.66
Particle size
Percentile:
other: MMAD
Mean:
4.08 µm
St. dev.:
2.66
Particle size distribution at different passagesopen allclose all
No.:
#1
Size:
10.4 µm
Distribution:
90.6 %
Remarks on result:
other: Cumulative amount less than indicated size
No.:
#2
Size:
7.7 µm
Distribution:
66.2 %
Remarks on result:
other: Cumulative amount less than indicated size
No.:
#3
Size:
4.1 µm
Distribution:
33.8 %
Remarks on result:
other: Cumulative amount less than indicated size
No.:
#4
Size:
1.3 µm
Distribution:
10.8 %
Remarks on result:
other: Cumulative amount less than indicated size
No.:
#5
Size:
0.9 µm
Distribution:
6.5 %
Remarks on result:
other: Cumulative amount less than indicated size
No.:
#6
Size:
0.56 µm
Distribution:
4.3 %
Remarks on result:
other: Cumulative amount less than indicated size

Any other information on results incl. tables

A preliminary evaluation of the substance was performed by sieve analysis using an Inclyno sieve shaker. 26.3% passed through a 100 µm sieve after a 33 minute period. The use of a sieve brushing technique to eliminate the influence of aggregation of the substance demonstrated that an aliquot of test substance passed completely through a 100 µm sieve, with no visible residue retained.


Therefore, definitive quantification was performed by cascade impactor analysis. A dust atmosphere was produced from the test substance using a SAG 410 Solid Aerosol Generator (TOPAS GmbH, Dresden, Germany) located adjacent to the atmosphere chamber and connected to a metered compressed air supply. The compressed air was supplied by means of an oil free compressor and passed through a water trap and respiratory quality filter before it was introduced to the aerosol generator. The cylindrical atmosphere chamber had a volume of about 30 L. The aerosol concentration in the chamber was measured at the time of atmosphere generation with a gravimetric method using glass fiber filters placed in a holder, and the actual measured concentrations were 2.06 and 3.14 mg/L. The particle size distribution of the test substance aerosol in the chamber was then determined in duplicate using a Marple Personal Cascade Impactor, consisting of a series of impactor stages with stainless steel collection substrates and a backup glass fibre filter housed in an aluminium sampler. The sampler was temporarily sealed in a sampling port in the chamber and a suitable, known volume of atmosphere chamber air was drawn through it using a vacuum pump. The collection substrate and backup filters were weighed before and after sampling and thw weight of test item, collected at each stage was calculated by difference.


The mass median aerodynamic diameter (MMAD) was calculated to be 4.08 µm. The geometric standard deviation was calculated to be 2.66 µm.  

Applicant's summary and conclusion

Conclusions:
The MMAD of the substance as determined by cascade impactor analysis was 4.08 µm and the geometric standard deviation was 2.66 µm.
Executive summary:

The particle size distribution of the substance was studied under GLP to European Commission Guidance Document EUR 20268, Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002).
A preliminary evaluation of the substance was performed by sieve analysis using an Inclyno sieve shaker. 26.3% passed through a 100 µm sieve after a 33 minute period. The use of a sieve brushing technique to eliminate the influence of aggregation of the substance demonstrated that an aliquot of test substance passed completely through a 100 µm sieve, with no visible residue retained.
Therefore, definitive quantification was performed by cascade impactor analysis. A dust atmosphere was produced from the test substance using a SAG 410 Solid Aerosol Generator (TOPAS GmbH, Dresden, Germany) located adjacent to the atmosphere chamber and connected to a metered compressed air supply. The compressed air was supplied by means of an oil free compressor and passed through a water trap and respiratory quality filter before it was introduced to the aerosol generator. The cylindrical atmosphere chamber had a volume of about 30 L. The aerosol concentration in the chamber was measured at the time of atmosphere generation with a gravimetric method using glass fiber filters placed in a holder, and the actual measured concentrations were 2.06 and 3.14 mg/L. The particle size distribution of the test substance aerosol in the chamber was then determined in duplicate using a Marple Personal Cascade Impactor, consisting of a series of impactor stages with stainless steel collection substrates and a backup glass fibre filter housed in an aluminium sampler. The sampler was temporarily sealed in a sampling port in the chamber and a suitable, known volume of atmosphere chamber air was drawn through it using a vacuum pump. The collection substrate and backup filters were weighed before and after sampling and thw weight of test item, collected at each stage was calculated by difference.
The mass median aerodynamic diameter (MMAD) was calculated to be 4.08 µm. The geometric standard deviation was calculated to be 2.66 µm.