Registration Dossier
Registration Dossier
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EC number: 203-419-9 | CAS number: 106-65-0
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF). QSAR model reporting format is presented in the file QMRF attached.
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- VEGA in silico platform v.1.1.5
- Year:
- 2 019
- Bibliographic source:
- Sludge (EC50) Toxicity model (ProtoQSAR/Combase) 1.0.0
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Test material
- Reference substance name:
- Dimethyl succinate
- EC Number:
- 203-419-9
- EC Name:
- Dimethyl succinate
- Cas Number:
- 106-65-0
- Molecular formula:
- C6H10O4
- IUPAC Name:
- dimethyl succinate
Constituent 1
- Specific details on test material used for the study:
- COC(=O)CCC(=O)OC
Results and discussion
Effect concentrations
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Remarks on result:
- other: NON-Toxic
Any other information on results incl. tables
The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 of the substance was predicted to be NON-Toxic (i.e. EC50>100 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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