Registration Dossier
Registration Dossier
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EC number: 279-075-9 | CAS number: 79135-28-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- other: study results
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- No guideline followed; 6 rabbits tested for skin irritation on intact and wound skin.
- GLP compliance:
- no
Test material
- Reference substance name:
- Acid Brown 303
- IUPAC Name:
- Acid Brown 303
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Preparation of test site:
- other: intact and wound
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 72 h
- Observation period:
- 24 and 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact and wound skin
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- intact and wound skin
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified within the CLP Regulation (EC 1272/2008)
- Conclusions:
- Not irritant to the skin.
- Executive summary:
Skin irritation test was performed on 6 rabbits on both intact and wound skin. 0.5 g of test substance was applied. Observations for effects in terms of erythema and oedema were done at 24 and 72 h after start of application.
Irritation score was 0 for all rabbits.
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