Registration Dossier
Registration Dossier
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EC number: 283-882-1 | CAS number: 84775-52-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Curcuma longa, Zingiberaceae.
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in chemico
- Remarks:
- Sample was sent to Bioneeds India Private Limited, Devarahosahally, Sompura Hobli, Nelamangala Taluk, Bangalore-562111
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 90 Days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- direct peptide reactivity assay (DPRA)
Test material
- Reference substance name:
- Curcuma longa, ext.
- EC Number:
- 283-882-1
- EC Name:
- Curcuma longa, ext.
- Cas Number:
- 84775-52-0
- Molecular formula:
- C15H22O
- IUPAC Name:
- (6S)-2-methyl-6-(4-methylphenyl)hept-2-en-4-one and 2-Methyl-6-(4-methylcyclohexa-2,4-dien-1-yl)hept-2-en-4-one and 2-methyl-6-(4-methylidene-1-cyclohex-2-enyl)hept-2-en-4-one
- Test material form:
- liquid: viscous
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Parameter:
- other: Peret peptide Depletion
- Value:
- 19.33
- Vehicle controls validity:
- not valid
- Negative controls validity:
- not valid
- Positive controls validity:
- not valid
- Remarks on result:
- other: Low Reactivity
Applicant's summary and conclusion
- Interpretation of results:
- other: The Skin sensitisation evaluation by "In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA)" for Turmeric Oil confirms it is classified as “Low Reactivity" or predicts as “Positive".
- Conclusions:
- The Skin sensitisation evaluation by "In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA)" for Turmeric Oil confirms it is classified as "Low Reactivity" or predicts as "Positive". The study is performed in compliance with guidelines OECD TG 442C.
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