Registration Dossier
Registration Dossier
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EC number: 224-764-1 | CAS number: 4482-25-1
Endpoint summary
Administrative data
Description of key information
Additional information
Acute tests on two trophic levels are available on analogue substance 1, i.e. the acute fish and aquatic (Dafnia) invertebrates toxicity.
The studies showed precipitation under the experimental conditions, setting the limit of testing at the solubility limits.
In particular, a study performed on Zebra fishes showed precipitation of the substance in the medium, setting the LC0, 96h at ca. 0.74 mg/l.
Another study, performed on Dafnia, after precipitation, gave results as EC50 (EC0), 48h = 1.24 mg/l (measured concentration, solubility limit under the test conditions).
Morover, due to the insolubility of the substance in water, a test for assessing acute toxicity on aquatic plants, in particular algae, has been considered not applicable and representative. In fact, based on the REACH Regulation, Annex VII, Column 2 (specific rules for adaptation from column 1) the algae study does not need to be conducted if there are mitigating factors indicating that the aquatic toxicity is unlikely to occur, for instance if the substance is highly insoluble in water (< 0.1 mg/l).
Based on the read across considerations. the target substance is therefore an insoluble substance for which no acute toxicity is possible to record at levels up to the water solubility , and which is not rapidly degradable in accordance with section 4.1.2.9.5. Moreover, it has a BCF <500 or LgKow < 4 (values that can trigger the long-term toxicity tests) and therefore does not suggest potential to bioaccumulate in a long-term toxicity study.
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