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Physical & Chemical properties

Partition coefficient

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Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 21, 2019 - June 25, 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Deviations:
yes
Remarks:
The temperature of the water bath was out of range for 6% of the duration of the main test (minimum 24.3 °C; maximum 26.5 °C; mean of 25.2 °C). This deviation was not considered to have affected the quality or the interpretation of the results obtained.
GLP compliance:
yes (incl. QA statement)
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Analytical method:
liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.4
Temp.:
21 °C
pH:
>= 3.95 - <= 4.01
Remarks on result:
other: determined from the quantitative analysis of C12 amphopropionic acid
Remarks:
the partition coefficient is expressed as its logarithm to base 10 (log10 Pow)
Key result
Type:
log Pow
Partition coefficient:
0.22
Temp.:
21 °C
pH:
>= 3.95 - <= 4.01
Remarks on result:
other: determined from the quantitative analysis of acrylic acid
Remarks:
the partition coefficient is expressed as its logarithm to base 10 (log10 Pow)
Conclusions:
The n-octanol/water partition coefficient of the test item was investigated from the individual determination of the partition coefficient of its main constituents. The partition coefficient of C12 amphopropionc acid was equal to 1.40. The partition coefficient of acrylic acid was equal to 0.22.
Executive summary:

The n-octanol/water partition coefficient of the test item was investigated in a GLP-compliant study performed in accordance with OECD Guideline 123 (Slow-Stirring Method) from the individual determination of the partition coefficient of its main constituents. The partition coefficient of C12 amphopropionc acid was equal to 1.40. The partition coefficient of acrylic acid was equal to 0.22.

Description of key information

The n-octanol/water partition coefficient of the test item was investigated in a GLP-compliant study performed in accordance with OECD Guideline 123 (Slow-Stirring Method) from the individual determination of the partition coefficient of its main constituents. The partition coefficient of C12 amphopropionc acid was equal to 1.40. The partition coefficient of acrylic acid was equal to 0.22. A partition coefficient of 1.40 was used as worst-case value for the test item.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.4
at the temperature of:
21 °C

Additional information

The n-octanol/water partition coefficient of the test item was investigated in a GLP-compliant study (Ricau, 2019) performed in accordance with standard methods, with minor deviations. The study is considered as reliable without restriction (Klimisch 1) and was selected as key study for the endpoint.