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Diss Factsheets

Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019-04-02 to 2019-08-22
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Principles of method if other than guideline:
Due to the fact that the test item showed no evaluable UV activity, a quantitative determination of the water solubility via HPLC with UV detection was not possible. Only a preliminiary test was conducted.
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Key result
Water solubility:
> 3 350 - < 3 910 g/L
Conc. based on:
test mat.
Remarks on result:
other: Based on prelim. Test

Table 1 Preliminary test of the water solubility

Amount of test item

[g]

Total volume of added
water [mL]

Stirring time
[min]

Remark

0.106

0.1

--

not dissolved

 

 

0.6

3*

dissolved

23.430

5

6*+ 35

not dissolved

 

 

6

~1145**

not dissolved

 

 

7

~960**

dissolved

Conclusions:
For the test item a water solubility between 3350 to 3910 g/L was determined according to OECD guideline 105.
Executive summary:

The water solubility of the test item was determined in a study according to OECD guideline 105. According to the preliminary test, described in OECD test guideline 105 (1995) and Regulation EC No. 440/2008 Method A.6, the water solubility at room temperature of the test item was estimated to be 3350 < cs < 3910 g/L.

Description of key information

For the test item a water solubility of 3350 g/L was determined according to OECD guideline 105.

Key value for chemical safety assessment

Water solubility:
3 350 g/L
at the temperature of:
25 °C

Additional information

The water solubility of the test item was determined in a study according to OECD guideline 105. According to the preliminary test, described in OECD test guideline 105 (1995) and Regulation EC No. 440/2008 Method A.6, the water solubility at room temperature of the test item was estimated to be 3350 < cs < 3910 g/L.