Registration Dossier
Registration Dossier
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EC number: 907-284-3 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
According to OECD QSAR Toolbox v4.3, Nexus DEREK and Danish QSAR Database, the mixture of Methyl Linolenate, Methyl linoleate and Methyl oleate is predicted as non-mutagenic for the Ames Mutagenicity test.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6 (QSPR model adapted specifically from OECD test guideline 471)
- Principles of method if other than guideline:
- The purpose of the in silico study was to predict the Ames Mutagenicity of the test item – multiconstituent containing Methyl Linolenate, Methyl linoleate and Methyl oleate. This prediction was performed using the following QSAR models:
* OECD QSAR Toolbox v4.3 (profiling results)
* Danish QSAR Database
The final consensus result for Ames mutagenicity was derived by applying a consensus method on the reliable results derived for individual models. - Type of assay:
- bacterial reverse mutation assay
- Specific details on test material used for the study:
- SMILES:
* Methyl Linolenate: O=C(OC)CCCCCCCC=CCC=CCC=CCC
* Methyl Linoleate: O=C(OC)CCCCCCCC=CCC=CCCCCC
* Methyl oleate: O=C(OC)CCCCCCCC=CCCCCCCCC - Species / strain / cell type:
- S. typhimurium, other: Not specified
- Remarks:
- QSAR Database
- Key result
- Species / strain:
- S. typhimurium, other: Not specified
- Genotoxicity:
- negative
- Remarks:
- QSAR predicted value
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
- Conclusions:
- According to OECD QSAR Toolbox v4.3, Nexus DEREK and Danish QSAR Database, the mixture of Methyl Linolenate, Methyl linoleate and Methyl oleate is predicted as non-mutagenic for the Ames Mutagenicity test.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
