Orthoperiodic acid

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vitro

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is a strong acid (pH ≤2.0) or base (pH =>11.5)

Justification for type of information:

The objective of this study was to evaluate the ability of the test material to activate the antioxidant/ electrophile responsive element (ARE)-dependent pathway in the KeratinoSens™ assay.
The test was started with a solubility test. The test material was dissolved in Dimethyl sulfoxide to a final concentration of 200 mM (clear colourless solution). The solution was vortexed and sonicated (10 minutes with a maximum temperature of 24.5 °C) to dissolve the test material. The 100-fold dilution of the test material in Dulbecco's Modified Eagle Medium showed no precipitation (2000 µM). This concentration was therefore selected as highest test concentration for the main assay.
However, due to the fact that the test material was a strong acid the main test was cancelled: According to the consolidated version of Regulation 1907 /2006, studies for skin sensitisation do not have to be performed if the substance is a strong acid (pH<=2.0).
Therefore it is concluded that the test material is not suitable to perform the KeratinoSens™ test.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018