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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 January 2018 - 31 October 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
[(8R,9S,10R,13S,14S,17R)-3-ethoxy-17-ethynyl-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
EC Number:
610-565-0
Cas Number:
50717-99-2
Molecular formula:
C24H32O3
IUPAC Name:
[(8R,9S,10R,13S,14S,17R)-3-ethoxy-17-ethynyl-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Test material form:
solid: particulate/powder
Details on test material:
Physical appearance: off-white powder
Storage conditions: at room temperature

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
181.2 °C
Decomposition:
yes
Decomp. temp.:
> 250 °C

Any other information on results incl. tables

Two experiments were performed to investigate the melting and boiling behaviour of the substance.

DSC EXPERIMENT 1

An endothermic peak was observed between 150°C and 200°C followed by an exothermic effect between 250°C at 347°C (see the illustration below). The extrapolated onset temperature of the first peak was181.696°C. The endothermic effect was most likely caused by melting of the test item. An exothermic effect was observed between between 250°C and 347°C and probably caused by reaction and/or decomposition of the test item.

After the experiment, a yellow/brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test item. 

 

DSC EXPERIMENT 2

In order to investigate the melting peak, in Experiment 2 heating was stopped directly after the melting effect.  The extrapolated onset temperature was180.738°C. After the experiment, a colourless molten residue remained in the sample container. It demonstrated that melting was the reason for the endothermic effect.

 

DATA HANDLING

The melting temperature was determined as the mean melting temperature of Experiment 1 and Experiment 2.

Applicant's summary and conclusion

Conclusions:
The melting temperature of the substance was determined to be 181.2°C.
Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 181.2°C.

Reaction and/or decomposition of the substance was observed at temperatures > 250°C.