Myo-Inositol, hexakis(dihydrogen phosphate), dodecasodium salt

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24 October 2017 to 20 November 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Guideline study as required by REACH regulation 1907/2006

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

27 July 1995

Deviations:

no

Remarks:

No deviations from the guideline were ascertained.

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

30 May 2008

Deviations:

no

Remarks:

No deviations from the guideline were ascertained.

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Name: dermofeel® PA-12
- CAS No.: 17211-15-3 (old CAS mentioned in study: 14306-25-3)
- EC No.: 241-253-9 (old EC mentioned in study: 238-242-6)
- Source and lot/batch No.of test material:
585542
- Appearance: white solid powder
- Production date: May 2016
- Expiration date of the lot/batch: May 2019

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
The test item was stored in the test facility in a closed vessel at room temperature
(16.0 – 21.6°C) protected from light and humidity.

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
The test item was ground and dried at least overnight. Drying was done in a desiccator.
- Preliminary purification step (if any): not applicable
- Final dilution of a dissolved solid, stock liquid or gel: not applicable
- Final preparation of a solid: not applicable

OTHER SPECIFICS:
Homogeneity: homogenous

Key result

Boiling pt.:

>= 92.61 - <= 113.18 °C

Atm. press.:

101.325 kPa

Decomposition:

no

Pre-test for boiling point following Siwoloboff

All observations are presented in the following table.

Table     Results of the pre-test for boiling point following Siwoloboff

Observations	Temperature
The test item stated to melt to a white mass like gel	74 °C
The test item melted completely, the amount of the test item after melting was about 1 / 5 of the amount at the beginning	90 °C
The test item foamed / boiled The liquid getting more transparent and moved upwards. The boiling is getting more violent.	110 °C
Turned off gas burner	Up to 120 °C
No more bubbles were visible	112 °C
Test item stayed as slightly yellowish transparent sticky mass	After cooling down

Interpretation

In all DSC measurements two endo thermic events were detected. According to the pre-tests the first event can be identified as melting point.

The second event can be identified as boiling point. As the deviation of melting and boiling point from three independent determinations are higher than 0.5 K, a range of melting and boiling point are stated.

Presentation of results

All results of boiling point are presented in the following table.

Table    Calculated values

Begin of decomposition	in °C	in K
1 Determination	113.18	386.33
2 Determination	109.06	382.21
3 Determination	92.61	365.76
Min	92.61	365.76
Max	113.18	386.33

Validity

As the deviations between determinations are > 0.5 K, a range of boiling point is stated.

Conclusions:

Boiling range evaluated by DSC: 92.61 °C to 113.18 °C (365.76 K to 386.33 K)

Executive summary:

The determination of the melting and boiling point of dermofeel® PA-12 was performed via DSC (differential scanning calorimetry). In all runs two events were detected. The events

are endothermic and the second event is stated as the boiling range under these circumstances as:

92.61 °C to 113.18 °C (365.76 K to 386.33 K)

No observations were made which might cause doubts on the validity of the study outcome.

Therefore, the result of the study is considered valid.

Description of key information

Boiling range is 92.61 °C to 113.18 °C (365.76 K to 386.33 K) (Method OECD 103; respectively to EC Guideline EU A.2; differential scanning calorimetry (DSC)).

Additional information

The melting and boiling point was determined via DSC (differential scanning calorimetry) according to the OECD Guideline 103 and EU Method A.2.

In all runs two events were detected. The events are endothermic and the second event is stated as the boiling range under these circumstances as:

92.61 °C to 113.18 °C (365.76 K to 386.33 K)

No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.