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EC number: 226-949-2 | CAS number: 5575-43-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation:
Irritating (rabbits)
Eye irritation:
Damaging (rabbits)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Sept 1989 - 6 Dec 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- other: albino Chbb-SPF
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2,2-2,7 kg
- Diet (e.g. ad libitum): ad libitum, regular rabbit diet
- Water (e.g. ad libitum): tsp water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 1 deg C
- Humidity (%): 60 +/- 5 %
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0,5 ml- Observation period:
- At 4, 24, 48 and 72 hours and 6, 8, 10 days after test material application skin reactions were recorded
- Number of animals:
- 3 animals
- Details on study design:
- Erythema and escar formation
0 no eryhema
1 very slight erythema
2 welll-defined erythema
3 moderate to severe erythema
4 Severe erythema andto slight escar formation
Oedema formation
0 no oedema
1 very slight oedema
2 slight oedema
3 moderate oedema
4 Severe oedema - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 8
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 dayd
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Irritant / corrosive response data:
- Scoring
Average (erythema + oedema)
0 - 0.5 no irritation
0.5 - 3.0 mild irritation
3.1 - 5.0 moderate irritation
5,1 - 8,0 strong irritation
Average Irritation index (oedema + erythema) 1hours - 72 hours was 1,73 (max 8). - Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The dermal irritation potential of tetrakis(2-ethylhexane-1,3-diolato) titanium was evaluated when applied to the skin of rabbits. The test material caused mild irritation.
- Executive summary:
Skin irritation of tetrakis(2 -ethylhexane-1,3 -diolato)titanium was tested on the back of rabbits. The product was applied undiluted and the intact skin was exposed 4 hours for the substance. The skin was washed to remove excess of test item. The erythema and oedema scores were recorded at 1, 4, 24, 48, 72 hours and 6, 8 and 10 days after test item removal. The susbstance demonstrated a slight rritant effect on the skin of male rabbits (irritatino index = 1.7 / 8).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The key study by Murmann, P (1989) investigated skin irritation potential of tetrakis(2 -ethylhexane-1,3 -diolato)titanium. The substance demonstrated a slight irritant effect on the skin of rabbits.
The supporting study on structurally similair substance (titanium tetrakis(2 -ethylhexanolate)) was used to evaluate the skin irritation of the substance.
A skin irritation study by Ferenz, R.L. (1978) was conducted for 5% and 50% solution of titanium tetrakis(2-ethylhexanolate). The test substance was applied on the skin of six rabbits for 24 hours. Skin reactions were observed at 24 and 48 hours following application. Based on the study report, the test material in 50% suspension was considered moderately irritating and in 5% suspension not irritating to the skin of guinea pigs.
Eye irritation
The key study by Murmann, P (1990) investigated eye irritation potential of tetrakis(2 -ethylhexane-1,3 -diolato)titanium. The substance demonstrated a mild irritant effect on the eyes of rabbits.
The supporting studies are available on structurally similair substance Titanium tetrakis(2 -ethylhexanolate). In the pre-guideline eye irritation study by Gargus, J.L. (1983) Titanium tetrakis(2 -ethylhexanolate) was applied undiluted into the eyes of rabbits. Observations were made at 1 and 4 hours, and at 1, 2, 3, 7, 14, and 21 days for the treated eyes. The test substance irritated the cornea and conjunctiva of rabbit eyes. In the other pre-guideline study by Ferenz, R.L. 1978 titanium tetrakis(2 -ethylhexanolate) was applied undiluted into the eyes of two rabbits. After 20 seconds, treated eye of one rabbit was washed with water. The treated eye of the other rabbit was not washed. Observations were made at 1 and 4 hours, and at 1, 2, 3, 7, 14, and 21 days for the treated eyes. Titanium tetrakis(2-ethylhexanolate) severely irritated the cornea and conjunctiva and moderately irritated the iris of both the washed and unwashed rabbit eyes. At 21 days, the unwashed eye had slight corneal opacity and the washed eye had mild to moderate corneal irritation.
This substance is hydrolytically unstable, releasing 2-ethylhexane-1,3-diol (CAS 94-96-2) and hydrated titanium dioxide (non-hazardous), when it comes in contact with water or moisture. Thus, the intrinsic properties of this substance are related to the hazards of 2-ethylhexane-1,3-diol (EHD). EHD has harmonised classification for Eye Dam 1 H 318. This classification is also assigned for the substance.
Justification for classification or non-classification
Based on the skin irritation information on the substance itself and on the structurally similair product, the substance has to be classified to hazard class Skin Irrit. 2 according to CLP Regulation 1272/2008.
Based on the eye irritation information on the substance itself and on the decomposition product (EHD), the substance has to be classified to hazard class Eye Dam 1 according to CLP Regulation 1272/200.
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