Registration Dossier
Registration Dossier
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EC number: 240-015-1 | CAS number: 15879-01-3
Endpoint summary
Administrative data
Description of key information
GPMT (OECD 406): Not sensitizing
Sensitisation study (No guideline followed) done for structurally similair substance: Not sensitizing
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The key study by Murmann, P (1990) investigated skin sensitizing potential of Titanium 2,2´,2´´-nitrilotrisethanolate. The substance demonstrated no sensitizing effect on the skin of female guinea pigs in the Magnusson-Kligman maximization test.
The supporting study on structurally similair substance (titanium tetrakis(2 -ethylhexanolate)) was used to evaluate the skin irritation of the substance.
At challenge no sensitization response was observed.
Data of the decomposition products is used for assessment, because the target substance is hydrolytically unstable having the half-life less than 10 minutes. Published information on titanium and TiO2 confirmed that there was no human evidence of skin sensitization, contact dermatitis or appreciable dermal absorption (Clayton & Clayton (eds.), 1981). There is also evidence of a lack of titanium compound toxicity to the skin demonstrated by its use in the therapy of skin disorders and as a biocompatible implant material (West & Wyzan, 1963 cited in WHO, 1982)
As a conclusion on skin sensitization, there is available enough reliable information to support the conclusion that tetrakis(2 -ethylhexane-1,3 -diolato)titanium is not skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Titanium 2,2´,2´´-nitrilotrisethanolate is not classified for skin sensitization in accordance to the CLP Regulation No. 1272/2008.
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