Registration Dossier
Registration Dossier
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EC number: 204-653-4 | CAS number: 123-81-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Deviations:
- yes
- Remarks:
- 24 h exposure, no scoring at 48 h
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at time of study
Test material
- Reference substance name:
- Ethylene di(S-thioacetate)
- EC Number:
- 204-653-4
- EC Name:
- Ethylene di(S-thioacetate)
- Cas Number:
- 123-81-9
- Molecular formula:
- C6H10O4S2
- IUPAC Name:
- ethane-1,2-diyl bis(sulfanylacetate)
Constituent 1
- Specific details on test material used for the study:
- not specified
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Remarks:
- no scoring at 48 h
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- no scoring at 48 h
- Time point:
- 24/48/72 h
- Score:
- 0.08
- Max. score:
- 4
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- GDMA is not irritating to skin. The deficiency of the study (no 48-h score) is more than compensated by the longer exposure time (24 instead of 4 h) and the occlusive exposure conditions.
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