Registration Dossier
Registration Dossier
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EC number: 217-359-6 | CAS number: 1824-74-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate
- EC Number:
- 217-359-6
- EC Name:
- 7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate
- Cas Number:
- 1824-74-4
- Molecular formula:
- C17H13ClN2O3
- IUPAC Name:
- 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- 3 albino male rabbits "Newzeland" with bw 2 kg to 3 kg
observation period: 3 days
Temp. 20°C (+/- 3°)
Relative humidity: 30-70 %
Lighting: 12 h light/ 12 h darkness
Feeding: Conventional feeding
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- Dose: 0.5 ml of the product
- Duration of treatment / exposure:
- test material was administered to an area of 6 cm2 of clipped intact skin for 4 hours.
- Observation period:
- 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The product analysed does not cause any edema nor erythema which could be detected after the 4 hours of contact of the sample within the test experimentation conditions.
Non corrosive and non irritant product by skin contact.
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