Gadolinium oxide sulfide (Gd2O2S), ytterbium-doped

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

GLP compliance:

yes

Type of method:

Laser scattering/diffraction

Type of particle tested:

agglomerate

Test material

Test material information

Constituent 1

Reference substance name:

Gadolinium oxide sulfide (Gd2O2S), ytterbium-doped

EC Number:

271-829-5

EC Name:

Gadolinium oxide sulfide (Gd2O2S), ytterbium-doped

Cas Number:

68609-44-9

Molecular formula:

(Gd1.7, Yb0.3)O2S

IUPAC Name:

Gadolinium oxide sulfide, ytterbium-doped

Test material form:

solid: particulate/powder

Results and discussion

Mass median aerodynamic diameter:

ca. 15.592 µm

Geometric standard deviation:

>= 1.277 - <= 1.312

Particle size

Particle size 1

Key result

Percentile:

D10

Mean:

< 2.89 µm

St. dev.:

2.89

Particle size 2

Key result

Percentile:

D50

Mean:

< 5.652 µm

St. dev.:

5.652

Particle size 3

Key result

Percentile:

D90

Mean:

< 10.771 µm

St. dev.:

10.772

Any other information on results incl. tables

Table 5:1: Summary of results using the dry powder module.

Particle Size Anaylsis using dry powder module (DPM)	Average (μm)
Volume weighted mean	6.321
Median	5.652
Mode	5.746
MMAD (mass median aerodynamic diameter)	15.592
d10 - 10 % of material is <	2.890
d50 - 50 % of material is <	5.652
d90 - 90 % of material is <	10.771
volume of sample < 10.00 μm	86.86 %

Table 8:1 Full Test Results

	RUN 1	RUN 2	RUN 3	RUN 4	RUN 5	Average **
Volume Weighted Mean	6.317	6.323	6.319	6.326	6.321	6.321
Median	5.654	5.655	5.647	5.653	5.650	5.652
Mode	5.753	5.751	5.738	5.745	5.741	5.746
MMAD *	15.597	15.600	15.578	15.596	15.586	15.592
d10 - 10 % of material is <	2.894	2.892	2.886	2.889	2.889	2.890
d50 - 50 % of material is <	5.654	5.655	5.647	5.653	5.650	5.652
d90 - 90 % of material is <	10.753	10.770	10.774	10.786	10.775	10.771

All results are in μm

* Mass median aerodynamic diameter

** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

86.86 % by volume of sample was seen to be < 10.00 μm.

Table 8:" Standard Deviation results.

Run No.	1	2	3	4	5	STDVP	% STDVP
d10 - 10 % of material is <	2.894	2.892	2.886	2.889	2.889	0.003	0.1
d50 - 50 % of material is <	5.654	5.655	5.647	5.653	5.650	0.003	0.1
d90 - 90 % of material is <	10.753	10.770	10.774	10.786	10.775	0.011	0.1
d15.78 - 15.78 % of material is <	4.426	4.393	4.362	4.337	4.305	0.042	1.0
GSD	1.277	1.287	1.295	1.303	1.312	0.012	0.9
MMAD	15.597	15.600	15.578	15.596	15.586	0.008	0.1

GSD = Geometric standard deviation of the lognormal particle size distribution (calculated from d50/d15.78)

STDVP = standard deviation of the population

% STDVP = percentage standard deviation of the population

Applicant's summary and conclusion

Conclusions:

The particle size distribution was determined by laser diffraction and the dry powder module in accordance with ISO 13320 and CIPAC MT 187. The Mass Median Aerodynamic Diameter was shown to be ca. 15.592 μm with a Geometric Standard Deviation of 1.277 to 1.312 . The percentile particle size, D10 of the substance analysed was < 2.890 μm, D50 of < 5.652 μm and the D90 of < 10.771 μm, with standard deviations of 2.89, 5.6518 and 10.7716 respectively.

Executive summary:

The particle size distribution of was determined by laser diffraction and the dry powder module in accordance with ISO 13320 and CIPAC MT 187. In which, a direct observation of fine off-white powder with clusters, 3.2 objective lens observation showing particles of irregular shaped crystals (approx. 3 μm with the largest size approx. 13 μm) and a 40 objective lens observation noting the sample is "made up of single crystalline particles" took place. The study was run 5 times and anaylysed via the Malvern Mastersizer 2000 Laser Diffraction Analyser. The average was reported as the final results. The Mass Median Aerodynamic Diameter was shown to be ca. 15.592 μm with a Geometric Standard Deviation of 1.277 to 1.312 . The percentile particle size, D10 of the substance analysed was < 2.890 μm, D50 of < 5.652 μm and the D90 of < 10.771 μm, with standard deviations of 2.89, 5.6518 and 10.7716 respectively.