Reaction mass of isomers of disodium amino-(3-carboxylatopropanamido)hexanoate and trisodium 2,6-bis(3-carboxylatopropanamido)hexanoate

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2 September 2016 - 31 January 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Version / remarks:

27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Version / remarks:

31 May 2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

plate method

Key result

Surface tension:

71.89 mN/m

Temp.:

19.5 °C

Conc.:

1 g/L

The surface tension of the negative control was determined with 73.17 mN/m at 18.7 °C, therefore showing a difference of 0.26% from the stated literature value. The difference lies within the accepted range of 1% deviation from literature value.

Table 1 Measured values test item first series

Measurement	Time	Mass	Surface Tension	Temperature
No	s	g	mN/m	°C
1	3.0	0.2931	71.50	19.5
2	6.0	0.2945	71.84	19.5
3	9.0	0.2950	71.96	19.5
4	12.0	0.2950	71.96	19.5
5	15.0	0.2949	71.94	19.5
6	18.0	0.2963	72.28	19.5
7	21.0	0.2936	71.62	19.5
8	24.0	0.2947	71.89	19.5
9	27.0	0.2957	72.13	19.5
10	30.0	0.2943	71.79	19.5
Mean			71.89
Standard Deviation			0.23

Table 2 Measured values test item second series

Measurement	Time	Mass	Surface Tension	Temperature
No	s	g	mN/m	°C
1	2.9	0.2926	71.38	19.9
2	5.9	0.2951	71.99	19.9
3	8.9	0.2952	72.01	19.9
4	11.9	0.2950	71.96	19.9
5	14.9	0.2950	71.96	19.9
6	17.9	0.2950	71.96	19.9
7	20.9	0.2950	71.96	19.9
8	23.9	0.2951	71.99	20.0
9	26.9	0.2953	72.04	20.0
10	29.9	0.2951	71.99	19.9
Mean			71.93
Standard Deviation			0.19

After the first and the second measurement series, the difference between mean values was less than 5%. Therefore no additional measurement series was required.

Conclusions:

The surface tension of an aqueous solution (1g/L) of the test item was determined as 71.89 ± 0.23 mN/m at 19.5 °C.

Executive summary:

A study was conducted according OECD TG 115 and EU method A.5 to determine the surface tension of an aqueous solution of the test item using the plate method. In the course of this study aqueous solutions were prepared containing 1 g/L test item in HPLC water. The test was performed with the help of K11HRX (Krüss) type tensiometer. The surface tension of the negative control HPCL water lay within the accepted range. The surface tension of an aqueous solution of the test item was determined as 71.89 ± 0.23 mN/m at 19.5 °C. One measurement was performed for verification (after 57 minutes). No significant changes and thus no significant dependence on time were observed. As these values were higher than 60 mN/m, the test item was classified as not surface active.

Description of key information

The surface tension of an aqueous solution (1g/L) of the test item was determined as 71.89 ± 0.23 mN/m at 19.5 °C.

Key value for chemical safety assessment

Surface tension:

71.89

in mN/m at 20°C and concentration in mg/L:

1 000

Additional information

A study was conducted according OECD TG 115 and EU method A.5 to determine the surface tension of an aqueous solution of the test item using the plate method. In the course of this study aqueous solutions were prepared containing 1 g/L test item in HPLC water. The test was performed with the help of K11HRX (Krüss) type tensiometer. The surface tension of the negative control HPCL water lay within the accepted range. The surface tension of an aqueous solution of the test item was determined as 71.89 ± 0.23 mN/m at 19.5 °C. One measurement was performed for verification (after 57 minutes). No significant changes and thus no significant dependence on time were observed. As these values were higher than 60 mN/m, the test item was classified as not surface active.