Registration Dossier
Registration Dossier
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EC number: 208-551-0 | CAS number: 533-00-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish, juvenile growth test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Insufficient details available to make a direct reliability assessment, however, inclusion in ECHA review article coupled with official OECD guideline being followed supportive of K2 reliability score.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 215 (Fish, Juvenile Growth Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Test type:
- semi-static
- Total exposure duration:
- 28 d
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks on result:
- other: The overall average of measured concentrations of the test substance in the test solutions was 94 -103 % of nominal.
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks on result:
- other: The overall average of measured concentrations of the test substance in the test solutions was 94 -103 % of nominal.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 28-day EC50 value was considered to be higher than 120 mg/L.
The 28-day NOEC value was considered to be higher than 120 mg/L.
Reference
Description of key information
A long-term toxicity study with fish is available. In the study (Pawlowski, 2004) with Oncorhynchus mykiss the NOEC >120 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 120 mg/L
Additional information
A long term toxicity study with fish is available indicating a NOEC > 120 mg/L nominal (concentrations measured within the desired ranges). The study (Pawlowski, 2004) was a semi-static 28 day study according to OECD 204 and 215.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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