Registration Dossier
Registration Dossier
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EC number: 929-011-7 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Data source
Reference
- Reference Type:
- other: prediction
- Title:
- QSAR prediction of benzyl-paroxetine base
- Author:
- Gedeon Richter Plc.
- Year:
- 2 016
- Bibliographic source:
- QSAR Toolbox
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- QSAR
Test material
- Reference substance name:
- (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine
- EC Number:
- 929-011-7
- Molecular formula:
- C26H26FNO3
- IUPAC Name:
- (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-1-benzyl-4-(4-fluorophenyl)piperidine
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 920 mg/kg bw
- Remarks on result:
- other: prediction
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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