Registration Dossier
Registration Dossier
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EC number: 240-968-3 | CAS number: 16919-19-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: aerosol was inhaled for 4 h
- Principles of method if other than guideline:
- aerosol was continiously inhaled for 4 h, concentration of test substance was controlled by potentiometric measurement of fluor
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium hexafluorosilicate
- EC Number:
- 240-968-3
- EC Name:
- Ammonium hexafluorosilicate
- Cas Number:
- 16919-19-0
- Molecular formula:
- F6Si.2H4N
- IUPAC Name:
- diammonium hexafluorosilicate
- Test material form:
- solid: particulate/powder
1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- potentiometric measurement of fluor
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 0.84 +/- 0.08 ; 9.6 +/- 0.6 ; 28.7 +/- 1.7 mg/m³
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- other: LOEL
- Effect level:
- ca. 9.6 mg/m³ air (analytical)
- Based on:
- element
- Remarks:
- fluor
- Exp. duration:
- 4 h
- Mortality:
- no
- Clinical signs:
- other: drop of orientation, declining numbers of erythrocytes and leukocytes, declining activities of cholinesterases and lactatdehydrogenase, change of alanin-aminotransferase activity, less breathing rate, more cellular particles after lavage
Applicant's summary and conclusion
- Conclusions:
- LOEL (inhalation of aerosol, 4 h exposition, rat) for ASF is 9.6 mg/m³.
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