Acetylcysteine

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable gases

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid

Reference 2

Endpoint:

pyrophoric liquids

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid

Reference 3

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Reference 4

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-06-05

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Test procedure:

100 mm sample cube at 140°C

Result:

negative outcome (no effect observed)

In the investigation of self-ignition in the Grewer Oven for the pure test item an endothermic process was detected starting at approx. 100 °C. The test item melted and flowed out of the basket. After the test, the wire basket was empty. No self-heating or self-ignition could be observed up to the melting of the test item.

Interpretation of results:

GHS criteria not met

Conclusions:

The test item has not to be classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.

Executive summary:

A test according to UN N.4 was performed to determine theself-ignition in the Grewer Oven of the test substance. The pure test item indicated no self-ignition at atmospheric pressure. It showed an endothermic effect starting at a temperature of approx. 100 °C and flowed out of the wire basket. The test item has not to be classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.

Reference 5

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

Description of key information

The substance has not to be classified as flammable gas, flammable liquid, flammable solid, pyrophoric solid, pyrophoric liquid, flammable in contact with water, flammable aerosol or self-heating substance.

Key value for chemical safety assessment

Flammability:

not classified

Additional information

Flammable solids

A test according to UN N.1 was performed to determine the flammability of the test substance. The test item was formed into a powder train. The flame from a gas burner was applied to one end of the powder train for 2 minutes. The burning of the pile was observed. The test was performed twice. In the preliminary test the test item could not be ignited. Based on the results of the preliminary test, no main test was performed. The test item is considered as a not readily combustible solid of Division 4.1. and is not a flammable solid (reference 4.13 -1).

 

Flammable liquids

In accordance with column 2 Annex VII section 7.9 of Regulation (EC) No 1907/2006 (REACH), the test on flash point does not need to be conducted as the test substance is solid.

 

Flammable gases

The test item is a solid at ambient conditions. This hazard class is only applicable for gases. Thus, the substance was not considered for classification as flammable gas.

 

Pyrophoric properties of liquids

The test item is a solid at ambient conditions. This hazard class is only applicable for liquids. Thus, the substance was not considered for classification as pyrophoric liquid.

 

Pyrophoric properties of solids

In accordance with section 2.10.4.1, Annex I of Regulation (EC) No 1272/2008, the classification procedure for pyrophoric solids need not to be applied when experience in manufacture or handling shows that the substance or mixture does not ignite spontaneously on coming into contact with air at normal temperatures (i.e. the substance is known to be stable at room temperature for prolonged periods of time (days)). Thus, no study was conducted and the substance was not considered for classification as pyrophoric solid.

 

Self-heating substances and mixtures

A test according to UN N.4 was performed to determine theself-ignition in the Grewer Oven of the test substance. The pure test item indicated no self-ignition at atmospheric pressure. It showed an endothermic effect starting at a temperature of approx. 100 °C and flowed out of the wire basket. The test item has not to be classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.

 

Substances which, in contact with water, emit flammable gases

In accordance with column 2 of REACH Annex VII and with Regulation (EC) No 1272/2008 Annex I, section 2.12.4.1(b) the classification procedure for this hazard class need not be applied. Based on the experience in handling and use the substance does not react with water and in addition the test substance is not pyrophoric. Thus, no study was conducted and the substance was not considered for classification.

Flammable Aerosols

In accordance with Annex I of Regulation (EC) No 1272/2008, section 2.3 the classification procedure for this hazard class does not apply, since the test substance is not used as an aerosol. Thus, no study was conducted and the substance was not considered for classification.

Justification for classification or non-classification

Classification, Labelling, and Packaging Regulation (EC) No 1272/2008

In accordance with Annex I section 2.2, section 2.3, section 2.6, section 2.7, section 2.9, section 2.10, section 2.11 and section 2.12 of Regulation (EC) No 1272/2008, as amended for tenth time in Regulation (EU) No 2017/776, and UN GHS Rev 7 (2017) the test item has not to be classified as flammable liquid, readily combustible solid in class 4, Division 4.1, self-heating substance in Class 4, Division 4.2, substance which in contact with water emits flammable gases in Class 4, Division 4.3, pyrophoric liquid, pyrophoric solid in class 4, Division 4.2, flammable gas in class 2 or as aerosol in class 2.