Hydrogen bis[1-[(5-chloro-2-hydroxyphenyl)azo]-2-naphtholato(2-)]chromate(1-)

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

February 2, 2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04 Dec 2017 - 23 Feb 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

2012

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)

Version / remarks:

2002

Deviations:

no

GLP compliance:

yes

Type of method:

air comparison pycnometer (for solids)

Specific details on test material used for the study:

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
The test item was dried in a desiccator under vacuum using silica gel as the drying agent at 19.8 ± 0.2°C for 70 hours.

Key result

Type:

relative density

Density:

1.55 other: dimensionless

Temp.:

20 °C

Remarks on result:

other: D 20 /4

Key result

Type:

density

Density:

1.55 g/cm³

Temp.:

20 °C

Relative density D20/4:

Experiment 1: 1.560

Experiment 2: 1.548

Mean: 1.55

Conclusions:

The relative density D20/4 of the substance was determined to be 1.55.

Executive summary:

The relative density of the solid substance was determined at 20°C using a gas comparison pycnometer in a GLP study according to EC A.3, OECD 109 and OPPTS 830.7300. The relative density D20/4 was determined in duplicate obtaining a mean value of 1.55.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

According to REACH Article 13(3) tests on substances shall be conducted in accordance with the test methods laid down in a Commission Regulation or in accordance with other international test methods recognised by the Commission or the Agency as being appropriate. No particle size distribution test method is laid down in regulation (EC) No 440/2008. OECD 110 TG ‘Particle Size Distribution/FibreLength and Diameter Distributions’ dates from 1981 and describes two methods in detail; both methods have restrictions and are not applicable to the entire size range. ECHA’s Guidance on information requirements and Chemical Safety Assessment-Chapter R.7a stipulates that many methods are available for particle size measurements but none of them is applicable to the entire size range. The guidance mentions Laser scattering/diffraction as a method for particles of all kind and makes reference to ISO 13320:2009.
According to Guidance document EUR 20268 (2002), the laser diffraction technique is applicable to particles of respirable and inhalable size. The MMAD can be calculated.

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

Hydrogen bis[1-[(5-chloro-2-hydroxyphenyl)azo]-2-naphtholato(2-)]chromate(1-)

EC Number:

250-774-0

EC Name:

Hydrogen bis[1-[(5-chloro-2-hydroxyphenyl)azo]-2-naphtholato(2-)]chromate(1-)

Cas Number:

31714-55-3

Molecular formula:

C32H19Cl2CrN4O4

IUPAC Name:

[1-{[5-chloro-2-(hydroxy-kappaO)phenyl]diazenyl}-2-naphtholato(2-)-kappaO]{1-[(5-chloro-2-hydroxyphenyl)diazenyl]-2-naphtholato-kappaO}chromium

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

Relative density: 1.55

Results and discussion

Mass median aerodynamic diameter:

2.33 µm

Particle size

Particle size 1

Key result

Percentile:

D10

Mean:

1.096 µm

Remarks on result:

other: St. dev. not available

Particle size 2

Key result

Percentile:

D50

Mean:

1.875 µm

Remarks on result:

other: St. dev. not available

Particle size 3

Key result

Percentile:

D90

Mean:

3.744 µm

Remarks on result:

other: St. dev. not available

Particle size distribution at different passages

No.:

#1

Size:

< 10 µm

Distribution:

100 other: vol%

Any other information on results incl. tables

Specific surface: 3.396 m2/cm3

Applicant's summary and conclusion

Conclusions:

Particle size distribution of the substance: D10 = 1.096 µm, D50 = 1.875 µm and D90 = 3.744 µm. 100% by volume was determined to be smaller than 10 µm. The MMAD was determined to be 2.33 µm.

Executive summary:

The particle size distribution of the substance was determined using laser diffraction analysis. The following results were obtained: D10 = 1.096 µm, D50 = 1.875 µm and D90 = 3.744 µm. 100% by volume was determined to be smaller than 10 µm. The MMAD was determined to be 2.33 µm.