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EC number: 220-621-2 | CAS number: 2835-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Study period:
- From August 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Based on the available in vivo oral acute study to investigate the oral LD50 , together with a toxicokinetics (ADME) study of topically applied compound, the acute inhalation toxic potential of 4-AMINO-m-CRESOL could be determined.
- GLP compliance:
- no
- Test type:
- other: Extrapolation calculation
Test material
- Reference substance name:
- 4-amino-m-cresol
- EC Number:
- 220-621-2
- EC Name:
- 4-amino-m-cresol
- Cas Number:
- 2835-99-6
- Molecular formula:
- C7H9NO
- IUPAC Name:
- 4-amino-m-cresol
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 12.24 mg/L air
- Based on:
- test mat.
Any other information on results incl. tables
Calculations: Maximum volume of exposure in 4 hours:
0.074 L/min x 60 min x 4 hours = 17.76 L
Determination of the correction factor oral vs. inhalation route:
Ratio of 105% oral : 100% inhalation = 1.0
Determination of the LC50 calc inhal.:
(870 mg/kg bw x 0.250 kg bw / 17.76L) × 1.0 = 12.24 mg/L
Result: LC50 calc inhal. 4-AMINO-m-CRESOL = 12.24 mg/L
Conversion of LC50 calc inhal. to % (w/w):
1 L air: 1.2041 kg/m³ = 1204.1 g/m³ = 1204100 mg/m³ = 1204100/1000 L = 1201 mg/L
1201 mg/L = 100 %
12.24 mg/L air = 1.011 % (w/w)
The concentration of 1.01% (w/w) 4-AMINO-m-CRESOL is lower than the concentration tested in the Draize test, at which concentration minimal irritation was observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the available acute oral toxicity and toxicokinetics data for 4-AMINO-m-CRESOL, the acute dermal, as well as acute inhalation, toxic potential for 4-AMINO-m-CRESOL could be calculated.
The calculated inhalation toxicity value for 4-AMINO-m-CRESOL (12.24 mg/l) is consistent with that of its analogue, 4-aminophenol (>3.42 mg/L). When this concentration is combined with the results of in vivo eye irritation studies, it can be concluded that 4-AMINO-m-CRESOL would not have a local effect in the lungs. Based on the LC50 , calc inhal. value, 4-AMINO-m-CRESOL should be classified as Acute Tox Cat.4; H332: “harmful if inhaled”, according to the Globally Harmonized System of Classification and Labeling (GHS). - Executive summary:
The acute oral toxicity of 4-AMINO-m-CRESOL was determined to be 870 mg/kg bw from a non-compliant study which was considered to be acceptable. Based on these data, 4-AMINO-m-CRESOL should be classified as Acute Tox Cat.4; H302: “harmful if swallowed”, according to the Globally Harmonized System of Classification and Labeling (GHS).
Based on the available acute oral toxicity and toxicokinetics data for 4-AMINO-m-CRESOL, the acute dermal, as well as acute inhalation, toxic potential for 4-AMINO-m-CRESOL could be calculated.
Calculations:
Maximum volume of exposure in 4 hours:
0.074 L/min x 60 min x 4 hours = 17.76 L
Determination of the correction factor oral vs. inhalation route:
Ratio of 105% oral : 100% inhalation = 1.0
Determination of the LC50 calc inhal.:
(870 mg/kg bw x 0.250 kg bw / 17.76L) × 1.0 = 12.24 mg/L
Result: LC50 calc inhal. 4-AMINO-m-CRESOL = 12.24 mg/L
The calculated inhalation toxicity value for 4-AMINO-m-CRESOL (12.24 mg/l) is consistent with that of its analogue, 4-aminophenol (>3.42 mg/L). When this concentration is combined with the results of in vivo eye irritation studies, it can be concluded that 4-AMINO-m-CRESOL would not have a local effect in the lungs. Based on the LC50 , calc inhal. value, 4-AMINO-m-CRESOL should be classified as Acute Tox Cat.4; H332: “harmful if inhaled”, according to the Globally Harmonized System of Classification and Labeling (GHS).
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