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EC number: 946-944-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1 October 1999 - 14 MArch 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C12-14 (even numbered), propoxylated, aminated
- EC Number:
- 946-944-5
- Molecular formula:
- C12H27N (C3H6O)n n=1-5, C14H31N (C3H6O)n n=1-4
- IUPAC Name:
- Alcohols, C12-14 (even numbered), propoxylated, aminated
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: test material was provided by the sponsor
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hare Marland
- Age at study initiation: 15 weeks
- Weight at study initiation: 2.767 - 3.067 kg
- Housing: individual
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-21
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 20 DEcember 1999 To: 3 January 2000
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5ml
- Concentration (if solution): neat
- Duration of treatment / exposure:
- The animals were exposed for 3min, 60min and 4h
- Observation period:
- The exposure sites were scored immediately after the exposure period and daily from day 2 to 15. In addition, the 3min exposure site was also scored approximately after 60min.
- Number of animals:
- 6 (3 males and 3 females)
- Details on study design:
- TEST SITE
- Area of exposure: dorsal trunk
- Type of wrap if used: gauze and semi-occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with mineral oil
- Time after start of exposure: substance was removed after 3min, 60min and 4h
OBSERVATION TIME POINTS
3min exposure: 3min, 60min, daily days 2-15
60min exposure: 60min, daily days 2-15
4h exposure: 4h, daily days 2-15
SCORING SYSTEM:
- Method of calculation: the effects were scored according to the Draize method.
The Primary Irritation Index (PII) was calculated according to OECD and OSHA
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- OECD
- Basis:
- mean
- Time point:
- other: immediate, 24h, 48h and 72h
- Score:
- 6.6
- Reversibility:
- not reversible
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- OSHA
- Basis:
- mean
- Time point:
- other: immediate and 48h
- Score:
- 5.4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Necrosis was observed in all animals tested with the test item during the duration of the study. After 3min exposure only very slight erythema and no edema was observed immediately after the exposure (2/6 animals) and 60min after exposure (5/6 animals).
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- The test item was found to be corrosive. DOT packing group classification II.
- Executive summary:
The purpose of the study was to determine the potential of the test item to have irritant/ corrosive effects when in contact with rabbit skin.
The test item was applied to 3 sites of the clipped dorsal trunk of New Zeland White rabbits. The exposure times for the different sites were 3min, 60min and 4h. Observation of dermal irritation and corrosivity was performed for each site immediately after the exposure and daily from day 2- 15. In addition, the 3min exposure site was also scored approximately after 60min. The grading of the irritation was according to the method of Draize.
Necrosis was observed in all animals tested with the test item during the duration of the study. After 3min exposure only very slight erythema and no edema was observed immediately after the exposure (2/6 animals) and 60min after exposure (5/6 animals).
The test item was found to be corrosive.
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