Registration Dossier
Registration Dossier
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EC number: 241-997-4 | CAS number: 18096-62-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14-Nov-2014 to 15-Nov-2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildeshelm
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.76
- Temp.:
- 22.8 °C
- pH:
- 7
- Conclusions:
- A log Pow value of 1.76 (at 22.8 °C) was determined for the test substance according to E.U Method A.8.
Reference
Results of Test Item Analysis
Retention time data and calculated log k values for the two isomer signals of the test item.
Two individual log Pow values for the test item were derived under consideration of the first and second calibration. Finally, a mean value was calculated from the individual log Pow values.
An individual log Pow value of 1.76 ± 0.07 (95 % CI 1.59 to 1.94) was obtained with both calibrations. The individual values did not differ more than ± 0.1 log Pow units.
Based on these data a mean value of 1.76 was derived.
Retention Times, Capacity Factors and Partition Coefficients of the test item
Test item: [TRADE NAME] |
tR(min) |
k |
Log k |
Log Pow |
|
2.959 |
4.449 |
0.648 |
1stcalibration |
2ndcalibration |
|
2.959 |
4.449 |
0.648 |
1.76+0.07 1.59 to 1.94 (95% CI) |
1.76+0.07 1.59 to 1.94 (95% CI) |
|
Mean |
2.959 |
4.449 |
0.648 |
1.76 |
|
tR: Retention time
k: Capacity factor test item
Pow: Partition Coefficient (n-octanol / water)
CI : Confidence Interval
Conclusions
Two individual log Pow values for the test item were derived under consideration of the first and second calibration. A mean value was calculated from these individual log Pow values. Based on this data a log Powvalue of 1.76 was determined for the test item.
Description of key information
Log Pow: 1.76 at 22.8 °C (EU Method A.8, HPLC method)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.76
- at the temperature of:
- 22.8 °C
Additional information
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