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Diss Factsheets
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EC number: 309-831-6 | CAS number: 101227-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- August 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Draize test
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Fatty acids, C16-18, 2-butyloctyl esters
- EC Number:
- 309-831-6
- EC Name:
- Fatty acids, C16-18, 2-butyloctyl esters
- Cas Number:
- 101227-08-1
- Molecular formula:
- C28H56O2 - C30H60O2
- IUPAC Name:
- Fatty acids, C16-18, 2-butyloctyl esters
- Test material form:
- other: liquid
Constituent 1
Method
- Details on study design:
- 27 human volunteers, controls not required
TEST SITE
- Area of exposure: not mentioned
- % coverage: no data
- Type of wrap if used: occlusive patch, no further details mentioned
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not done, however the patch sites were then wiped gently with a dry cotton ball
- Time after start of exposure: 48 h
SCORING SYSTEM:
see table #1 below
The subjects were infonned of the nature of the test, including possible adverse reactions. Written infonned consent was obtained.
Additionally, the subjects were considered dependable and able to read and understand instructions. The subjects did not exhibit any physical or dennatological condition that would have precluded application of the test article.
The subjects were requested to report to the testing facility any delayed reactions which might occur after the last reading. If necessary, readings were taken at additional time periods after application. - Details on exposure:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 mL undiluted
Duration of treatment / exposure: 4 h
Observation period: 1 h and 48 h
Results and discussion
- Results:
- not irritating
Any other information on results incl. tables
Phase I and II: Transient, barely-perceptible (+) non-specific patch test responses were observed on I to 4 (1/27 to 4/27 or 3.6% to 14.2% of the test population) test panelists under the patch test conditions described for Phase I and Phase II of the study. None of these responses was considered evidence of clinically meaningful irritation potential.
Phase III: No skin reactivity was observed during the course of the study.
Applicant's summary and conclusion
- Conclusions:
- Erythema score (mean): 0
Oedema score (mean): 0
Under the patch test conditions described for Phases I, II and III of the study the test substance did not show any evidence of primary irritation potential in human subjects. - Executive summary:
Under the patch test conditions described for Phases I, II and III of the study the test substance did not show any evidence of primary irritation potential in human subjects.
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