Registration Dossier
Registration Dossier
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EC number: 210-568-3 | CAS number: 618-88-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17.3.-1.4.2008
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 5-nitroisophthalic acid
- EC Number:
- 210-568-3
- EC Name:
- 5-nitroisophthalic acid
- Cas Number:
- 618-88-2
- Molecular formula:
- C8H5NO6
- IUPAC Name:
- 5-nitroisophthalic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- aqua for injectione
- Doses:
- 2000 mg/kg> 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- 30 minutes after intoxication: piloerection, gibbous posture.3 hours after intoxication: piloerection, anaemic mucous membranes, gibbous posture.2 nd - 14 th day after intoxication: no clinical signs.
- Gross pathology:
- Without pathologic changes (all six animals).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
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