Sodium prop-2-enesulphonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: In principle according to OECD 403, however analytical determination of the atmosphere concentration was not performed; the exposure time was 8h; method and results are poorly described in the report (however raw data are available)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

analytical determination, exposure time 8 h

GLP compliance:

no

Test type:

other: inhalation risk test

Test material

Test material information

Constituent 1

Reference substance name:

Sodium prop-2-enesulphonate

EC Number:

219-676-5

EC Name:

Sodium prop-2-enesulphonate

Cas Number:

2495-39-8

Molecular formula:

C3H6O3S.Na

IUPAC Name:

sodium prop-2-ene-1-sulfonate

Details on test material:

- Name of test-item: Golpanol SC 9269 = Golpanol ALS
- Purity: 25 % in aqua dest.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: 238 g (male), 181,3 g (female)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 200 L air/h

TEST ATMOSPHERE
- Brief description of analytical method used: Inhalation of a vapour-saturated atmosphere at 20°C. For saturation air was disposed through a 5 cm thick product layer. The calculated vapour saturation for the a. i. is 0.00002 µg/L.

VEHICLE
- Composition of vehicle (if applicable): air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

Concentration was stated to be 4.71 mg/L calculated reweighing of the product column after exposure. Due to the very low vapour pressure ( 3e-09 hPa at 25°C) / vapour saturation (0.00002 µg/L) of the a. i. it is assumed that this substance loss is mainly based on loss of water.

No. of animals per sex per dose:

6

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was done on day 0 and day 7. No informations about observation times.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: IHT

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: Mortality: 0/12 animals died after exposure to a saturated vapour atmosphere.

Mortality:

0/12 died

Clinical signs:

other: Strong mucosa irritation, eyelid closure on the day of exposure. The first day after exposure there were no abnormalities detected anymore.

Body weight:

The mean body weights of the animals were in the normal range throughout the study period.

Gross pathology:

No abnormalities detected.