Registration Dossier
Registration Dossier
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EC number: 206-137-4 | CAS number: 303-26-4
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The half life of hydrolysis of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine was estimated by using OECD QSAR tool box v3.3 and closest read across chemicals with log Kow as primary descriptor. The half life of hydrolysis of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine was estimated to be 244.66 days. Based on half life of hydrolysis value it is concluded that this test chemical is not hydrolysable.
Additional information
Hydrolysis:
Predicted data study for target chemical chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine and two experimental studies for its structurally similar read across cchemical have been conducted and their results are summarized below.
In first weight of evidence study the half life of hydrolysis of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine was estimated by using OECD QSAR tool box v3.3 and closest read across chemicals with log Kow as primary descriptor. The half life of hydrolysis of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine was estimated to be 244.66 days. Based on half life of hydrolysis value it is concluded that this test chemical is not hydrolysable.
Next weight of evidence study was done by using authoritative database (HSDB, 2017) in this study the read across chemical 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid (CAS no.83881-51-0) is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions On the basis of this it is concluded that this read across chemical is not hydrolysable.
Last weight of evidence study was also done from authoritative database (HSDB, 2017) in study another read across chemical 1-(2-Aminoethyl) piperazine (CAS no.140-31-8) is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions On the basis of this it is concluded that this read across chemical is not hydrolysable.
On the basis of all the studies mentioned above it can be concluded that target chemical1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no. 303-26-4) is not hydrolysable.
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