Registration Dossier
Registration Dossier
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EC number: 281-692-3 | CAS number: 84012-52-2
Endpoint summary
Administrative data
Description of key information
Not skin sensitizer
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No tests are available on the substance in itself, nevertheless the skin sensitisation potential of the target substance was assessed by means of the Read Across approach. The complete Justification for the Read Across is detailed at section 13.
Two tests were proposed in order to complete the assessment:
The selected key study [Huntsman Textile Effects GmbH, 1979] was conducted according to the AFDO Method on the Similar Substance 02. Under the test condition no animal showed positive reaction, therefore under the test condition the substance is considered as non sensitizer for skin.
Even the second study was conducted on the Similar Substance 02, reported as supporting study [Huntsman Textile Effects GmbH, 1979], and showed no positive reaction on the tested animals.
The key study was chosen due to the purity of the test item higher than the one of the supporting study.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) 3.4.1.2 Skin sensitiser means a substance that will lead to an allergic response following skin contact. The experiment conducted in read across clearly shows that the substance is not capable to produce positive reactions after treatment with the test substance and no toxic symptoms were recorded.
Basred on the experimental results the test article is considered a non sensitizer and no classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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