Registration Dossier
Registration Dossier
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EC number: 256-050-0 | CAS number: 43035-18-3
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- The study does not need to be conducted because the physicochemical properties of the substance indicate that it can be expected to have a low potential for adsorption - Waiver 1: According to the following Guidance documents the OECD TG 106 is not applicable to nanomaterials: “In general, TG 106 (Adsorption - Desorption Using a Batch Equilibrium Method) will not provide reliable results for nanomaterials as they do not establish a thermodynamic equilibrium with any substrate. This GD does not apply to dissolved chemicals but to nanomaterials.”, (GUIDANCE DOCUMENT FOR THE TESTING OF DISSOLUTION AND DISPERSION STABILITY OFNANOMATERIALS AND THE USE OF THE DATA FOR FURTHER ENVIRONMENTAL TESTING AND ASSESSMENT STRATEGIES, Series on Testing and Assessment No. 318). “TG 106 Adsorption - Desorption Using a Batch Equilibrium Method is not applicable to applicable to nanomaterials because it is currently not possible to differentiate between adsorbed or aggregated/agglomerated nanoparticles settled during the centrifugation step, and a new TG needs to be developed”., Guidance Document R 7.1. for nanomaterials applicable to chapter R7a, v 2.0, chapter 2.2.4.) According to the EUON overview of Reach requirements and available Methods, a Draft OECD guidance document on testing nanomaterial behaviour in soils using OECD test guideline 312 is expected in 2020 or 2021. Therefor no valid test system is currently available and testing is technically no feasible. Waiver 2: The registration substance is practically insoluble and have a negligible vapour pressure . Due to an estimated n-octanol/water partitioning coefficient below the trigger value of three, a low adsorption potential to sediment and soil particles can be expected. Therefor waiving according to ”column 2” in Annex VIII and IX of REGULATION (EC) No 1907/2006 (low absorption potential - logPow < 3) is also justified.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
