N-benzyl-4-methoxy-α-methylphenethylamine

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 July - 30 July 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

not specified

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

N-benzyl-4-methoxy-α-methylphenethylamine

EC Number:

256-155-1

EC Name:

N-benzyl-4-methoxy-α-methylphenethylamine

Cas Number:

43229-65-8

Molecular formula:

C17H21NO

IUPAC Name:

N-benzyl-1-(4-methoxyphenyl)propan-2-amine

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report): TH 1165 II
- Physical state: Yellow liquid
- Analytical purity: 98.2 % (area)
- Density: 1.05 g/ml (determined at NOTOX)
- Lot/batch No.: 61
- Expiration date of the lot/batch: 8 April 2000 (allocated by NOTOX, 1 year after receipt of the test substance)
- Stability under test conditions: not indicated
- Storage condition of test material: at room temperature in the dark

Results and discussion

Water solubility

Water solubility:

> 0.1 - < 0.2 g/L

Temp.:

19.5 °C

pH:

9.4

Any other information on results incl. tables

Test 1

The test substance in the nominal 0.1 g/l solution had dissolved completely after the 5.75 hours stirring period. The pH of this solution was 9.4. In the mixture of 10 g/l and 1135 g/l, there was still undissolved test substance observed after the 5.75 hours stirring period. The temperature was 19.0 +/- 0.5°C during the stirring period.

Test 2

In the mixture of 0.5 g/l and 1 g/l, there was still undissolved test substance observed after the 48 hours stirring period. The temperature was 19.5 +/- 1.5°C during the stirring period.

Test 3

In the mixture of 0.2 g/l, 0.3 g/l and 0.4 g/l, there was still undissolved test substance observed after an approximately 28 hours stirring period. The temperature was 20.5 +/- 0.5°C during the stirring period.

Applicant's summary and conclusion

Conclusions:

Because the 0.1 g/l solution was a clear solution and because in the nominal 0.2 g/l solution undissolved test substance was observed visually, it was concluded that the water solubility of TH 1165 II is between 0.1 and 0.2 g/l at 19.5 +/- 1.5°C. The pH of the 0.1 g/l solution was 9.4.