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EC number: 203-499-5 | CAS number: 107-52-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are no reliable aquatic toxicity data available for tetradecamethylhexasiloxane (L6, CAS 107-52-8) therefore good quality data for the structurally-related substances decamethyltetrasiloxane (L4, CAS 141-62-8) and dodecamethylpentasiloxane (L5, CAS 141-63-9) have been read across.
Reliable short-term toxicity test results are available for freshwater fish (Oncorhynchus mykiss) read across from dodecamethylpentasiloxane (L5, CAS 141-63-9) and decamethyltetrasiloxane (L4, 141-62-8). The relevant short-term values are:
KEY: Fish: LC50 (96 h): >75 ng/l (0.000075 mg/l); NOEC ≥75 ng/l (0.000075 mg/l) based on geometric mean measured concentrations, read across from L5.
Supporting: Fish: LC50 (96 h): >6.3 μg/l (>0.0063 mg/l) and NOEC of ≥6.3 μg/L (>= 0.0063 mg/l) based on geometric mean measured concentrations, read across from L4.
The requirement for conducting a short-term test with Daphnia has been waived on the basis that there are reliable read-across long-term toxicity data available with invertebrates.
A reliable toxicity test result is available for algae (Pseudokirchneriella subcapitata) read-across from decamethyltetrasiloxane (L4, CAS 141-62-8). The relevant short-term values are:
Algae: EC50 (72 h): >2.2 μg/l (>0.0022 mg/l); NOEC: ≥2.2 μg/l (≥0.0022 mg/l) determined for the effects of decamethyltetrasiloxane on growth rate of the freshwater algae Pseudokirchneriella subcapitata, based on geometric mean measured concentrations.
A reliable long-term toxicity test result is available for freshwater fish (Oncorhynchus mykiss) read across from decamethyltetrasiloxane (L4, CAS 141-62-8) . The relevant long-term value is:
Fish: NOEC (60 d): ≥7.9 µg/l (≥0.0079 mg/l) determined for the effects of L4 (CAS 141-62-8) on hatching, larval survival, abnormal appearance and behaviour of Oncorhynchus mykiss, based on time weighted mean measured concentrations.
A reliable long-term toxicity test results is available for freshwater invertebrates (Daphnia magna) read across from dodecamethylpentasiloxane (L5, CAS 141-63-9). The relevant long-term value is:
Invertebrates: EC50 (21 d): >47 ng/l (0.000047 mg/l) and NOEC of ≥47 ng/l (0.000047 mg/l) have been determined for the effects of L5 on adult mortality, reproduction and growth of Daphnia magna. The data have been obtained in flow-through tests and are expressed relative to mean measured concentrations of the substance.
These concentrations were measured in test media prepared at a nominal concentration that corresponded with the water solubility of the substance (70 ng/l). It is thought that the low water solubility and high log Kowof siloxanes with slow hydrolysis limits the bioavailability in aquatic studies and toxicity is not expressed.
There are no reliable data available for toxicity to microorganisms.
An activated sludge respiration inhibition 3 hour EC50 value of >100 mg/l (nominal) was determined in a reliable study read across from decamethyltetrasiloxane, L4, (CAS 141 -62 -8).
There are no reliable data with the test substance available for toxicity to sediment organisms. Data have been read across from a structural analogue, L5, for three organisms (Chironomus riparius, Lumbriculus variegatus and Hyalella azteca). The data show no effects at the limit of solubility in organic carbon:
WoE: 28 day NOEC ≥38 mg/kg dry weight normalised to 5% organic carbon, based on mean measured concentrations, for the effects of L5 on survival and biomass of Lumbriculus variegatus.
WoE: 28 day NOEC ≥27 mg/kg dry weight normalised to 5% organic carbon, based on mean measured concentrations, for the effects of L5 on emergence and combined developmental rate of Chironomus riparius.
WoE: 28 day NOEC ≥52 mg/kg dry weight normalised to 5% organic carbon, based on mean measured concentrations, for the effects of L5 on survival and growth of Hyalella azteca.
In all cases these studies indicate no effects at the highest concentration tested, which in the case of the aquatic studies represents the limit of solubility of the tested substances. These data are read across as evidence that the registration substance would not be expected to exhibit toxic effects at its limit of solubility in test medium, which is similar to or lower than these read-across substances.
Refer to IUCLID Section 6 endpoint summary (CSR Section 7.0) for further discussion of the approach to chemical safety assessment and justification for read across.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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