Registration Dossier
Registration Dossier
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EC number: 203-124-5 | CAS number: 103-56-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from Danish QSAR.
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 103-56-0
- Author:
- Danish (Q)SAR Database
- Year:
- 2 017
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Data is taken from Danish QSAR
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Cinnamyl propionate
- EC Number:
- 203-124-5
- EC Name:
- Cinnamyl propionate
- Cas Number:
- 103-56-0
- Molecular formula:
- C12H14O2
- IUPAC Name:
- cinnamyl propionate
- Test material form:
- liquid
- Details on test material:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3600mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 3600mg/kg bw on rat for test substance Cinnamyl propionate (103-56-0).
- Executive summary:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 3600mg/kg bw on rat for Cinnamyl propionate(103-56-0)having Reliability Index: 0.87(high prediction quality)
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