Registration Dossier
Registration Dossier
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EC number: 209-924-0 | CAS number: 598-22-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 2005 - January 2006
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Propionyl bromide
- EC Number:
- 209-924-0
- EC Name:
- Propionyl bromide
- Cas Number:
- 598-22-1
- Molecular formula:
- C3H5BrO
- IUPAC Name:
- propanoyl bromide
- Test material form:
- liquid
Constituent 1
In vivo test system
Study design: in vivo (LLNA)
- Vehicle:
- other: Dried cotton seed oil
- Concentration:
- 2.5, 5 & 10% (v/v)
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Results
- Key result
- Parameter:
- SI
- Value:
- >= 0.95 - <= 3.31
- Remarks on result:
- positive indication of skin sensitisation based on QSAR/QSPR prediction
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
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