Registration Dossier
Registration Dossier
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EC number: 271-114-8 | CAS number: 68515-88-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authorized database
Data source
Reference
- Reference Type:
- other: Authorized database
- Title:
- Acute oral toxicity study of CAS no 68515-88-8
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus A TOXNET DATABASE, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction
- Principles of method if other than guideline:
- Prediction is done by using Danish QSAR
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Pentene, 2,4,4-trimethyl-, sulfurized
- EC Number:
- 271-114-8
- EC Name:
- Pentene, 2,4,4-trimethyl-, sulfurized
- Cas Number:
- 68515-88-8
- Molecular formula:
- C24H50S8
- IUPAC Name:
- 1-(2,4,4-trimethyl-1-{[(2,4,4-trimethylpentan-2-yl)disulfanyl]disulfanyl}pentan-2-yl)-4-(2,4,4-trimethylpentan-2-yl)tetrasulfane
- Details on test material:
- SMILES:CC(C)(C)CC(C)(C)SSSSCC(C)(CC(C)(C)C)SSSSC(C)(C)CC(C)(C)C
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Pentene, 2, 4, 4-trimethyl-, sulfurized
- Molecular formula (if other than submission substance): C24H50S8
- Molecular weight (if other than submission substance): 594-658 g/mole
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3641 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 641 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be >3641 mg/kg when rat treated with Pentene, 2, 4, 4-trimethyl-, sulfurized orally.
- Executive summary:
In acute oral toxicity study, rats were treated with Pentene, 2, 4, 4-trimethyl-, sulfurized orally. 50 % mortality observed at 3641 mg/kg bw. Therefore,LD50 was considered to be>3641 mg/kg when rat treated with Pentene, 2, 4, 4-trimethyl-, sulfurizedorally.
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