2-methylpent-2-enal

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1950 - 1954

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No guideline study. No GLP.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1954

Reference 2

Reference Type:

review article or handbook

Title:

no data

Author:

N.N.

Year:

2011

Bibliographic source:

Registry of Toxic effects Of Chemical Substances (RTECS) - AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute inhalation toxicity.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylpent-2-enal

EC Number:

210-789-5

EC Name:

2-methylpent-2-enal

Cas Number:

623-36-9

Molecular formula:

C6H10O

IUPAC Name:

2-methylpent-2-enal

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: raised in own colony
- Age at study initiation: no data
- Weight at study initiation: 90 to 120 grm
- Fasting period before study: no
- Housing: no data
- Diet: Rockland rat diet complete
- Water: no data
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

IN-LIFE DATES: no data

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

Inhalation of known vapor concentrations bv rats is conducted with flowing streams of vapors prepared by various styles of proportioning pumps. Nominal concentrations are recorded, not conflrmed by analytical methods. Exposures are four hours long. The concentration yielding fractional mortality among six rats within 14 days was recorded.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

Concentrations are in an essentially logarithmic series with a factor of two.

No. of animals per sex per dose:

6 males

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

LD50 values and their fiducial range are estimated by the method of Thompson 1) using the tables of Weil 2).

1) Thompson, W. R.: Use of Moving Averages and Interpolation to Estimate Median-Effective Dose, Bact. Rev. 11:115, 1947.
2) Weil, C. S.: Tables for Convenient Calculation of Median-Effective Dose and Instructions in Their Use, Biometrics 8:249, 1952.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

8 100 mg/m³ air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: equivalent to 2000 ppm/4 h

Mortality:

No mortality was observed up to a max. exposure time of 1 h (2000 ppm).
After 4 h exposure 3 of 6 animals were found dead within the observation period of 14 days.

Applicant's summary and conclusion

Conclusions:

2-Methyl-2-pentene-1-al showed an acute inhalation LC50 of 8100 mg/m³ air/4h in rats.