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EC number: 200-922-5 | CAS number: 75-98-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is with probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
Experimental data are available from a study conducted equivalently to OECD 203 using O. latipes (MOE, Japan, 2017). In this study the pH was not adjusted. Therefore, the pH of the test upper limit concentration deviated from the ideal test conditions. The pH of the test liquid at the upper limit concentration (100 mg/L) was 5.4 - 5.7 throughout the exposure period. According to the Chemical Substances Control Law Test Guidelines, an additional test with pH-adjusted test concentrations should be carried out, if the pH is not in the recommended range of 6 - 8.5.
However, the pKa of this test substance is 4.69 (estimated value; SPARC on-line calculator, http://sparc.chem.uga.edu/sparc/). The substance was, therefore, considered to be dissociated to an amount of ca. 90% at the pH of 5.4 – 5.7. If adjusted to a pH of 7.8 - 8.0, it would be 100% dissociated. The study results indicate 0% mortality at the upper limit concentration (100 mg/L), with an inappropriate pH and when the test substance is ca. 90% dissociated. Therefore, it was assumed that raising the pH of the test liquid in order to give 100% dissociation would not affect the mortality rate. Consequently, and in terms of animal welfare, it was decided not to carry out an additional study with adjustment of the pH.
In addition, the acute toxicity of propanoic acid, 2,2 -dimethyl- (CAS 75-98-9) to fish was investigated in a static test conducted equivalently to OECD 203 using O. mykiss as test organism (Hexion, 1997). Based on nominal test concentrations the 96-h LC50 was considered to be >300 mg/L as no mortality was observed within the exposure period of 96-h at the highest test concentration of 300 mg/L (96-h NOEC = 300 mg/L); in this study the pH of test solutions was adjusted. These data were selected as key data in terms of the chemical safety assessment.
Propanoic acid, 2,2 -dimethyl- (CAS 75 -98 -9) is concluded to be with high probability acutely not harmful to fish.
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