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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1969
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The method, test conditions and design were not sufficiently detailed.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: list VII
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum, J.S.
Year:
1969
Bibliographic source:
J. American Ind. Hgy. Assoc., 30 (5):470-476
Reference Type:
publication
Title:
Range-finding toxicity data: list VI
Author:
Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum, J.S.
Year:
1962
Bibliographic source:
J. American Ind. Hgy. Assoc, 23, 95-107

Materials and methods

Principles of method if other than guideline:
The method of Draize used was briefly described in the publication of Smyth et al. (1962). 4 male albino New Zealand albino rabbits/dose were exposed to substance using occlusive dressing and using a logarythmic series of doses.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,2-trichloroethane
EC Number:
201-166-9
EC Name:
1,1,2-trichloroethane
Cas Number:
79-00-5
Molecular formula:
C2H3Cl3
IUPAC Name:
1,1,2-trichloroethane
Details on test material:
Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.

Test animals

Species:
rabbit
Strain:
other: New Zealand albino
Sex:
male
Details on test animals or test system and environmental conditions:
Animals were weighing 2.5 to 3.5 kg.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
Fur was removed from the entire trunk by clipping, and dose was retained beneath an impervious plastic film. Animals were immobilised during the 24-h contact period, after which the film is removed and the rabbits are caged for the subsequent 14-day observation period.
Duration of exposure:
24 h
Doses:
logarythmic series of doses differing by a factor of 2
No. of animals per sex per dose:
4 males/dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the Method of Thompson (1947) using the tables of Weil (1952).

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 5 380 mg/kg bw
95% CL:
ca. 4 760 - ca. 6 072
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 3.73 mL/kg bw
95% CL:
ca. 3.3 - 4.21
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

The LD50 value was reported to be 3.73 mL/kg (corresponding to 5.38 g/kg).

Applicant's summary and conclusion

Conclusions:
In this acute dermal toxicity study conducted with mice, the LD50 value was reported to be 5.38 g/kg (3.73 mL/kg).
Executive summary:

In this acute dermal toxicity study conducted with mice according to Draize's Method, 4 male albino New Zealand albino rabbits/dose were exposed to substance using occlusive dressing and using a logarythmic series of doses.

The LD50 value was reported to be 5.38 g/kg (3.73 mL/kg).