Registration Dossier
Registration Dossier
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EC number: 209-987-4 | CAS number: 600-22-6
Endpoint summary
Administrative data
Description of key information
Acutely not toxic to aquatic organisms.
Methyl pyruvate is very unstable in contact with water and hydrolysis rapidly into pyruvate and methanol. A large amount of data on the toxicity of methanol is available for a broad spectrum of aquatic organisms (fish, invertebrates and algae). The results from the most reliable and relevant available studies are listed below.
The second hydrolysis product is pyruvate for which no data on aquatic toxicity are available. However, pyruvate can be encymatically reduced by lactate dehydrogenase to produce lactic acid. Both molecules are structural closely related and of central improtance for the celluar metabolism. There is an ECHA dessiminated dossier available which proves lactic acid to be acutely not toxic to auqatic organisms.
Short-term toxicity of methanol:
Fish
LC50 (96h) = 28100 mg/L Pimephales promelas
LC50 (96h) = 20100 mg/L Oncorhynchus mykiss
LC50 (96h) = 15400 mg/L Lepomis macrochirus
Daphnids
EC50 (48h) = 18000 mg/L Daphnia magna
EC50 (48h) > 10000 mg/L Daphnia magna
Green algae
EC50 (96h) ca. 22000 mg/L Selenastrum capricornutum
Short-term toxicity of lacic acid (ECHA dessiminated data):
Fish
LC50 (96h) = 130 mg/L Oncorhynchus mykiss
LC50 (96h) = 195 mg/L Danio rerio
LC50 (96h) = 130 mg/L Lepomis macrochirus
Daphnids
EC50 (48h) = 750 mg/L Daphnia magna
EC50 (48h) = 130 mg/L Daphnia magna
Green algae
EC50 (96h) > 2800 mg/L Pseudokirchneriella subcapitata
All the available data demonstrate consistently the very low acute toxicity to methanol and pyruvate (via read-across to lactic acid) for aquatic organisms.
Additional information
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