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Diss Factsheets
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EC number: 944-232-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An aerosol of the undiluted test material was generated by passing clean, dry air (-40°C dewpoint) through an Ohio Ball-Jet Nebulizer. The resulting air and aerosol mixture was introduced into the exposure chamber.
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction product of 3,9-dibromobenzanthrone condensed with 2 equivalents of 1-aminoanthraquinone, subsequently further condensed under oxidative conditions
- EC Number:
- 944-232-9
- Molecular formula:
- Not available - UVCB substance
- IUPAC Name:
- Reaction product of 3,9-dibromobenzanthrone condensed with 2 equivalents of 1-aminoanthraquinone, subsequently further condensed under oxidative conditions
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult rats were employed as test animals. The rats were selected after having been under observation for at least 5 days to insure their general health and suitability for testing.The animals were housed in stainless steel cages and permitted a standard laboratory diet plus water ad libitum, except during inhalation exposure.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- other: Not specified
- Remark on MMAD/GSD:
- No data
- Details on inhalation exposure:
- Test animals were exposed in a specially constructed inhalation chamber. The chamber was designed so that the animals could be introduced into the test atmosphere after the maximum aerosol concentration was established. Each animal was caged separately during exposure to minimize filtration of inspired air by animal fur.An aerosol of the undiluted test material was generated with an Ohio Ball-Jet Nebulizer. The stream of clean, dry air (-40°C dewpoint) was passed through the nebulizer. The resulting air and aerosol mixture was then introduced into the exposure chamber at the top center, dispersed by a baffle plate and exhausted at the bottom of the chamber. Air flow rate through the system was measured with a rotameter connected upstream of the nebulizer. The rotameter was calibrated with a wet-test meter after the exposure was completed. The average nominal aerosol concentration was calculated by dividing the nebulizer weight loss by the total volume of air used during the test.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 15,750 mg/m3 air
- No. of animals per sex per dose:
- 10 animal (5 male/5 female)
- Control animals:
- no
- Details on study design:
- 14 day observation period. During the exposure period, observations were made with respect to incidence of mortality and reactions displayed. At the end the exposure period, the rats were returned to their cages for observation.A body weight was determined for each animal prior to inhalation exposure and for each surviving animal at the end of the observation period. The data were recorded as an index to growth.Gross pathologic examinations were scheduled to be conducted upon all animals which might succumb during the test period and upon those sacrificed at the end of the observation period.
- Statistics:
- Not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 15 750 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no untoward reactions during exposure or the 14-day observation period which followed.
- Clinical signs:
- other: There were no untoward reactions during exposure or the 14-day observation period which followed.
- Body weight:
- The average 2-week body weight gains were within the normal limits.
- Gross pathology:
- Necropsy, performed on all rats at the end of the observation period, did not reveal any gross pathologic alterations.
- Other findings:
- No further findings reported.
Any other information on results incl. tables
Results
Group No. |
Total Number of Animals Male/Female |
Nominal Concentration |
Mortality Male-Female |
Weight Gain Male-Female (grams) |
I |
5/5 |
15,750 mg/m3air |
0/5 – 0/5 |
120-38 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LC50 >15,750 mg/m3 air
- Executive summary:
Charles River Rats were exposure for 4 hours.
An aerosol of the undiluted test material was generated by passing clean, dry air (-40°C dewpoint) through an Ohio Ball-Jet Nubulizer. The resulting air and aerosol mixture was introduced into the exposure chamber.
There were no untoward reactions during exposure or the 14-day observation period which followed. The average 2-week boy weight gains were within the normal limits. Necropsy, performed on all rats at the end of the observation period, did not reveal any gross pathologic alterations.
Acute LC50: >15,750 mg/m3air
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