Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-305-9 | CAS number: 1555-58-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish
Key value for chemical safety assessment
Additional information
Experimental data on the acute toxicity to fish are not available for 3,3'-(methylimino)bispropiononitrile (CAS 1555 -58 -4). Therefore, the acute toxicity to fish was assessed using several QSAR models.
The QSAR Toolbox v3.4.0.17 was used to derive two LC50 values by trend analysis. The substance is within the applicability domain of these valid and reliable (RL 2) models (BASF SE, 2016). The models use different aquatic toxicity databases and category definitions via functional groups.
The 96 -h LC50 was 176 and 120 mg/L.
The acute toxicity was also estimated by ECOSAR v1.11 (US EPA, 2012). The substance was assigned to two ECOSAR classes: Aliphatic amines and Polyaliphatic nitriles. The substance is within the applicability domain of both chemical classes. The LC50 was calculated to be 2235 mg/L as aliphatic amine and 16420 mg/L as polyaliphatic nitrile (BASF SE, 2016).
T.E.S.T. v4.2.1 (US EPA, 2016) was used to calculate the LC50 with the consenus method (BASF SE, 2016). The substance is within the applicability domain of the model; however, based on the mean average error, the confidence in the result may be low. The LC50 was calculated to 164 mg/L.
In a weight-of-evidence approach, it can be concluded that all the results are valid and within the applicability domain of the models. The LC50s are all within the same acute aquatc toxicity classification band of > 100 mg/L. Therefore, the substance is assessed to be with high probability to be acutely not harmful to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
