Registration Dossier
Registration Dossier
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EC number: 620-219-0 | CAS number: 39066-18-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Ethanone, 2-chloro-1-(3-chloro-4-hydroxyphenyl)-
- Cas Number:
- 39066-18-7
- Molecular formula:
- C8 H6 Cl2 O2
- IUPAC Name:
- Ethanone, 2-chloro-1-(3-chloro-4-hydroxyphenyl)-
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- yes
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: mean 24-72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 144 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: mean 24-72 hours
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 120 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean 24-72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 120 hours
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: mean 24-72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 144 hours
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: mean 24-72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 120 hours
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: mean 24-72 hours
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 120 hours
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The product showed a very slight to well-defined irritant, but no corrosive effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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