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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
review article or handbook
Title:
Skin irritation test of chemical Chloral
Author:
E. I. DUPONT DE NEMOURS AND COMPANY
Year:
1992
Bibliographic source:
TSCATS low detailed report, OTS0571236,year-1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
Skin irritation test of chemical was conducted on guinea pigs at different concentrations.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetaldehyde
EC Number:
200-911-5
EC Name:
Trichloroacetaldehyde
Cas Number:
75-87-6
Molecular formula:
C2HCl3O
IUPAC Name:
2,2,2-trichloroacetaldehyde
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Chloral
- Molecular formula: C2HCl3O
- Molecular weight: 147.3879 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C=O)(Cl)(Cl)Cl
- InChl: 1S/C2HCl3O/c3-2(4,5)1-6/h1H

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
2%, 5% and 10% of test chemical solution
Duration of treatment / exposure:
not specified
Observation period:
not specified
Number of animals:
not specified
Details on study design:
not specified

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Remarks:
10%-Strongly irritating
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Remarks:
5%-Moderately irritating
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
no indication of irritation
Remarks:
2%-Not irritating

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
A 10% solution was strongly irritating, a 5% solution was mildly to moderately irritating, and a 2% solution was not irritating. Thus on the basis of results obtained, it can be concluded that the given test chemical can cause irritation at higher concentration and can be considered as irritating to the skin of guinea pigs.
Executive summary:

Skin irritation test was conducted on guinea pigs to evaluate the skin irritant potency of test chemical. The test chemical was applied to the skin of guinea pigs at concentration of 2, 5 and 10% solution and the reactions were read. A 10% was strongly irritating, a 5% solution was mildly to moderately irritating, and a 2% solution was not irritating. On the basis of results obtained, it can be concluded that the given test chemical can cause irritation at higher concentration and can be considered as irritating to the skin of guinea pigs.