3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

March 1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well described summary report. Dose, number of animals (with details), experimental design and observation period are described in the study.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

not present at the time of performance.

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene

EC Number:

255-138-6

EC Name:

3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene

Cas Number:

40910-49-4

Molecular formula:

C14H26O2

IUPAC Name:

1-[(3,7-dimethylocta-1,6-dien-3-yl)oxy]-1-ethoxyethane

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report): Elintaal
- Description: clear, colourless liquid

Test animals

Species:

rat

Strain:

other: Wistar-derived

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: from TNO colony
- Age at study initiation: young adults
- Weight at study initiation: males: 135 - 248 g; females: 153 - 196 g
- Fasting period before study: overnight
- Housing: housed in groups of five animals in screen-bottomed stainless steel cages
- Diet: stock diet ad libitum
- Water: tap water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 -25
- Humidity (%): no data
- Air changes (per hr): well-ventilated
- Photoperiod (hrs dark / hrs light): no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

DOSE VOLUME APPLIED: 1.25, 2.5, 5.0 and 10.0 mL/kg body weight

No. of animals per sex per dose:

3

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 mL/kg bw

Based on:

test mat.

Mortality:

No deaths occurred.

Clinical signs:

other: All animals looked quite healthy throughout the observation period.

Gross pathology:

No data

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

In an acute oral toxicity with rats, an LD50 >10 mL/kg bw was determined.

Executive summary:

Elintaal was tested in an acute oral toxicity study with male and female rats at 1.25, 2.5, 5.0 and 10.0 mL/kg body weight. No deaths occurred. All animals looked quite healthy throughout the observation period. Based on the results, an LD50 >10 mL/kg bodyweight was determined.